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1

Correlation of Naturally Occurring HIV-1 Resistance to DEB025 with Capsid Amino Acid Polymorphisms

Gallay, Philippe, Ptak, Roger, Bobardt, Michael, Dumont, Jean-Maurice, Vuagniaux, Grégoire, Rosenwirth, Brigitte

Journal:

Year:

2013

Language:

english

File:

PDF, 382 KB

english, 2013

2

The cyclophilin inhibitor Debio-025 shows potent anti–hepatitis C effect in patients coinfected with hepatitis C and human immunodeficiency virus

Robert Flisiak, Andrzej Horban, Philippe Gallay, Michael Bobardt, Suganya Selvarajah, Alicja Wiercinska-Drapalo, Ewa Siwak, Iwona Cielniak, Jozef Higersberger, Jarek Kierkus, Christian Aeschlimann, Pi

Journal:

Year:

2008

Language:

english

File:

PDF, 522 KB

english, 2008

3

Human immunodeficiency virus type 1 hijacks host cyclophilin A for its attachment to target cells

Andrew C. S. Saphire, Michael D. Bobardt, Philippe A. Gallay

Journal:

Immunologic Research

Year:

2000

Language:

english

File:

PDF, 88 KB

english, 2000

4

In vitro Anti-hepatitis C Virus (HCV) Activities and Resistance Profile of Debio 025, A Non-immunosuppressive Cyclophilin Binding Molecule

Lotte Coelmont, Philippe Gallay, Michael Bobardt, Suzanne Kaptein, Jan Paeshuyse, Inge Vliegen, Grégoire Vuagniaux, Johan Neyts

Journal:

Antiviral Research

Year:

2009

Language:

english

File:

PDF, 76 KB

english, 2009

5

Activity of Novel Cyclophilin Inhibitors based on the Polyketide, Sanglifehrin A, against HIV

Michael Bobardt, Steven Moss, Udayan Chatterji, Mohammad Nur-E-Alam, Tony Warneck, Barrie Wilkinson, Philippe Gallay, Matthew Gregory

Journal:

Antiviral Research

Year:

2011

Language:

english

File:

PDF, 77 KB

english, 2011

6

Effect of polyanion-resistance on HIV-1 infection

Michael D Bobardt, Mercedes Armand-Ugón, Imma Clotet, Zhe Zhang, Guido David, Jose A Este, Philippe A Gallay

Journal:

Year:

2004

Language:

english

File:

PDF, 641 KB

english, 2004

7

HCV resistance to cyclosporin A does not correlate with a resistance of the NS5A–cyclophilin A interaction to cyclophilin inhibitors

Udayan Chatterji, Precious Lim, Michael D. Bobardt, Stefan Wieland, Daniel G. Cordek, Gregoire Vuagniaux, Francis Chisari, Craig E. Cameron, Paul Targett-Adams, Tanya Parkinson, Philippe A. Gallay

Journal:

Journal of Hepatology

Year:

2010

Language:

english

File:

PDF, 770 KB

english, 2010

8

88 PARTICULAR IN VITRO ANTI-HCV ACTIVITIES AND RESISTANCE PROFILE OF THE CYCLOPHILIN INHIBITOR DEBIO 025

L. Coelmont, P. Gallay, M. Bobardt, S. Kaptein, J. Paeshuyse, I. Vliegen, G. Vuagniaux, J. Neyts

Journal:

Journal of Hepatology

Year:

2009

Language:

english

File:

PDF, 50 KB

english, 2009

9

789 PRECLINICAL CHARACTERIZATION OF NOVEL CYCLOPHILIN INHIBITORS BASED ON THE POLYKETIDE, SANGLIFEHRIN

S.J. Moss, M. Bobardt, N. Coates, U. Chatterji, T. Foster, P. Gallay, A. Habel, S. Kendrew, P. Leyssen, C.J. Martin, J. Neyts, M. Nur-e-Alam, S. Obeid, J. Paeshuyse, D. Suthar, T. Warneck, B. Wilkinso

Journal:

Journal of Hepatology

Year:

2011

Language:

english

File:

PDF, 43 KB

english, 2011

10

Syndecan Captures, Protects, and Transmits HIV to T Lymphocytes

Michael D Bobardt, Andrew C.S Saphire, Hsiu-Cheng Hung, Xiaocong Yu, Bernadette Van der Schueren, Zhe Zhang, Guido David, Philippe A Gallay

Journal:

Year:

2003

Language:

english

File:

PDF, 842 KB

english, 2003

11

Sustained Local Delivery of Structurally Diverse HIV-1 Microbicides Released from Sublimation Enthalpy Controlled Matrices

Simi Gunaseelan, Philippe A. Gallay, Michael D. Bobardt, Charlene S. Dezzutti, Timothy Esch, Richard Maskiewicz

Journal:

Pharmaceutical Research

Year:

2012

Language:

english

File:

PDF, 579 KB

english, 2012

12

Inhibition of HIV Env binding to cellular receptors by monoclonal antibody 2G12 as probed by Fc-tagged gp120

James M Binley, Stacie Ngo-Abdalla, Penny Moore, Michael Bobardt, Udayan Chatterji, Philippe Gallay, Dennis R Burton, Ian A Wilson, John H Elder, Aymeric de Parseval

Journal:

Year:

2006

Language:

english

File:

PDF, 513 KB

english, 2006

13

Corrections: Inhibition of HIV Env binding to cellular receptors by monoclonal antibody 2G12 as probed by Fc-tagged gp120

James M Binley, Stacie Ngo-Abdalla, Penny Moore, Michael Bobardt, Udayan Chatterji, Philippe Gallay, Dennis R Burton, Ian A Wilson, John H Elder, Aymeric de Parseval

Journal:

Year:

2007

Language:

english

File:

PDF, 132 KB

english, 2007

14

Erratum to: Sustained Local Delivery of Structurally Diverse HIV-1 Microbicides Released from Sublimation Enthalpy Controlled Matrices

Simi Gunaseelan, Philippe A. Gallay, Michael D. Bobardt…

Journal:

Pharmaceutical Research

Year:

2013

Language:

english

File:

PDF, 66 KB

english, 2013

15

HCV NS5A and IRF9 compete for CypA binding

Bobardt, Michael, Hopkins, Sam, Baugh, James, Chatterji, Udayan, Hernandez, Felicia, Hiscott, John, Sluder, Ann, Lin, Kai, Gallay, Philippe A.

Journal:

Journal of Hepatology

Year:

2013

Language:

english

File:

PDF, 1.24 MB

english, 2013

16

O9 BOTH CYCLOPHILIN INHIBITORS AND DIRECT-ACTING ANTIVIRALS PREVENT PKR ACTIVATION IN HCV-INFECTED CELLS

Bobardt, M., Gallay, P.

Journal:

Journal of Hepatology

Year:

2014

Language:

english

File:

PDF, 63 KB

english, 2014

17

P1044 NVP018, A CYCLOPHILIN INHIBITOR FOR TREATMENT OF CHRONIC HBV INFECTION

Nilsson, J., Moss, S., Coates, N., Bobardt, M., Gallay, P., Gregory, M.

Journal:

Journal of Hepatology

Year:

2014

Language:

english

File:

PDF, 56 KB

english, 2014

18

833 DOWN-REGULATION OF INTERFERON-STIMULATED GENES AFTER ALISPORIVIR INTERFERON-FREE TREATMENT SUGGESTS A UNIQUE ANTIVIRAL MECHANISM OF ACTION FOR ALISPORIVIR, A CYCLOPHILIN INHIBITOR

Kaiser, S., Gallay, P., Bobardt, M., Bolognani, F., Hartmann, N., Letzkus, M., Rasul, R., Bao, W., Staedtler, F., Johnson, K.J., Moulin, P., Avila, C., Naoumov, N.V., Nirmala, N., Li, B.

Journal:

Journal of Hepatology

Year:

2013

Language:

english

File:

PDF, 58 KB

english, 2013

19

Sa1033 Interferon-Free Alisporivir Treatment Down-Regulates Interferon-Stimulated Genes Suggesting a Unique Antiviral Mechanism of Action for the Cyclophilin Inhibitor Alisporivir

Kaiser, Sergio, Gallay, Philippe, Bobardt, Michael, Bolognani, Federico, Hartmann, Nicole, Letzkus, Martin, Rasul, Rashad, Bao, Weibin, Staedtler, Frank, Johnson, Keith J., Moulin, Pierre, Avila, Clau

Journal:

Gastroenterology

Year:

2013

Language:

english

File:

PDF, 521 KB

english, 2013

20

P764 ANALYSIS OF THE EFFECT OF CYCLOPHILIN INHIBITOR ALISPORIVIR ON THE INTERFERON RESPONSE IN HCV-INFECTED CELLS AND PATIENTS

Bobardt, M., Baugh, J., Gallay, P., Ma, S., Kaiser, S., Hartmann, N., Letzkus, M., Staedtler, F., Riva, A., Chokshi, S., Nirmala, N.R., Johnson, K.J., Brass, C.A., Naoumov, N.V., Li, B.

Journal:

Journal of Hepatology

Year:

2014

Language:

english

File:

PDF, 64 KB

english, 2014

21

Alisporivir Inhibition of Hepatocyte Cyclophilins Reduces HBV Replication and Hepatitis B Surface Antigen Production

Phillips, Sandra, Chokshi, Shilpa, Chatterji, Udayan, Riva, Antonio, Bobardt, Michael, Williams, Roger, Gallay, Philippe, Naoumov, Nikolai V.

Journal:

Gastroenterology

Year:

2015

Language:

english

File:

PDF, 1.04 MB

english, 2015

22

PD 404,182 Is a Virocidal Small Molecule That Disrupts Hepatitis C Virus and Human Immunodeficiency Virus

Chamoun, A. M., Chockalingam, K., Bobardt, M., Simeon, R., Chang, J., Gallay, P., Chen, Z.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2012

Language:

english

File:

PDF, 1.26 MB

english, 2012

23

Cyclophilin and NS5A Inhibitors, but Not Other Anti-Hepatitis C Virus (HCV) Agents, Preclude HCV-Mediated Formation of Double-Membrane-Vesicle Viral Factories

Chatterji, Udayan, Bobardt, Michael, Tai, Andrew, Wood, Malcolm, Gallay, Philippe A.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2015

Language:

english

File:

PDF, 996 KB

english, 2015

24

Bioengineering and Semisynthesis of an Optimized Cyclophilin Inhibitor for Treatment of Chronic Viral Infection

Hansson, Magnus Joakim, Moss, Steven James, Bobardt, Michael, Chatterji, Udayan, Coates, Nigel, Garcia-Rivera, Jose A., Elmér, Eskil, Kendrew, Steve, Leyssen, Pieter, Neyts, Johan, Nur-E-Alam, Mohamma

Journal:

Chemistry & Biology

Year:

2015

Language:

english

File:

PDF, 1.13 MB

english, 2015

25

Multiple Mutations in Hepatitis C Virus NS5A Domain II Are Required To Confer a Significant Level of Resistance to Alisporivir

Garcia-Rivera, J. A., Bobardt, M., Chatterji, U., Hopkins, S., Gregory, M. A., Wilkinson, B., Lin, K., Gallay, P. A.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2012

Language:

english

File:

PDF, 1.99 MB

english, 2012

26

Trim5 Accelerates Degradation of Cytosolic Capsid Associated with Productive HIV-1 Entry

Chatterji, U., Bobardt, M. D., Gaskill, P., Sheeter, D., Fox, H., Gallay, P. A.

Journal:

Journal of Biological Chemistry

Year:

2006

Language:

english

File:

PDF, 1.01 MB

english, 2006

27

Syndecan-3 is a dendritic cell-specific attachment receptor for HIV-1

de Witte, L., Bobardt, M., Chatterji, U., Degeest, G., David, G., Geijtenbeek, T. B. H., Gallay, P.

Journal:

Proceedings of the National Academy of Sciences

Year:

2007

Language:

english

File:

PDF, 496 KB

english, 2007

28

Cell-Free Human Immunodeficiency Virus Type 1 Transcytosis through Primary Genital Epithelial Cells

Bobardt, M. D., Chatterji, U., Selvarajah, S., Van der Schueren, B., David, G., Kahn, B., Gallay, P. A.

Journal:

Journal of Virology

Year:

2007

Language:

english

File:

PDF, 599 KB

english, 2007

29

Syndecans Serve as Attachment Receptors for Human Immunodeficiency Virus Type 1 on Macrophages

Saphire, A. C. S., Bobardt, M. D., Zhang, Z., David, G., Gallay, P. A.

Journal:

Journal of Virology

Year:

2001

Language:

english

File:

PDF, 263 KB

english, 2001

30

Inhibition of Human Immunodeficiency Virus Type 1 Replication in Human Cells by Debio-025, a Novel Cyclophilin Binding Agent

Ptak, R. G., Gallay, P. A., Jochmans, D., Halestrap, A. P., Ruegg, U. T., Pallansch, L. A., Bobardt, M. D., de Bethune, M.-P., Neyts, J., De Clercq, E., Dumont, J.-M., Scalfaro, P., Besseghir, K., Wen

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2008

Language:

english

File:

PDF, 767 KB

english, 2008

31

Sublimable C5A Delivery Provides Sustained and Prolonged Anti-HIV Microbicidal Activities

Maskiewicz, R., Bobardt, M., Chatterji, U., Gunaseelan, S., Dezzutti, C. S., Penin, F., Gallay, P. A.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2012

Language:

english

File:

PDF, 1013 KB

english, 2012

32

Cyclophilin A-independent recruitment of NS5A and NS5B into hepatitis C virus replication complexes

Chatterji, U., Bobardt, M. D., Lim, P., Gallay, P. A.

Journal:

Journal of General Virology

Year:

2010

Language:

english

File:

PDF, 259 KB

english, 2010

33

trans-Complementation Rescue of Cyclophilin A-Deficient Viruses Reveals that the Requirement for Cyclophilin A in Human Immunodeficiency Virus Type 1 Replication Is Independent of Its Isomerase Activity

Saphire, A. C. S., Bobardt, M. D., Gallay, P. A.

Journal:

Journal of Virology

Year:

2002

Language:

english

File:

PDF, 724 KB

english, 2002

34

Cyclophilin A Plays Distinct Roles in Human Immunodeficiency Virus Type 1 Entry and Postentry Events, as Revealed by Spinoculation

Saphire, A. C. S., Bobardt, M. D., Gallay, P. A.

Journal:

Journal of Virology

Year:

2002

Language:

english

File:

PDF, 152 KB

english, 2002

35

Preclinical Characterization of Naturally Occurring Polyketide Cyclophilin Inhibitors from the Sanglifehrin Family

Gregory, M. A., Bobardt, M., Obeid, S., Chatterji, U., Coates, N. J., Foster, T., Gallay, P., Leyssen, P., Moss, S. J., Neyts, J., Nur-e-Alam, M., Paeshuyse, J., Piraee, M., Suthar, D., Warneck, T., Z

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2011

Language:

english

File:

PDF, 425 KB

english, 2011

36

Hepatitis C virus NS5A anchor peptide disrupts human immunodeficiency virus

Bobardt, M. D., Cheng, G., de Witte, L., Selvarajah, S., Chatterji, U., Sanders-Beer, B. E., Geijtenbeek, T. B. H., Chisari, F. V., Gallay, P. A.

Journal:

Proceedings of the National Academy of Sciences

Year:

2008

Language:

english

File:

PDF, 1.41 MB

english, 2008

37

Syndecan-Fc Hybrid Molecule as a Potent In Vitro Microbicidal Anti-HIV-1 Agent

Bobardt, M. D., Chatterji, U., Schaffer, L., de Witte, L., Gallay, P. A.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2010

Language:

english

File:

PDF, 1.90 MB

english, 2010

38

Evaluation of PD 404,182 as an Anti-HIV and Anti-Herpes Simplex Virus Microbicide

Chamoun-Emanuelli, A. M., Bobardt, M., Moncla, B., Mankowski, M. K., Ptak, R. G., Gallay, P., Chen, Z.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2014

Language:

english

File:

PDF, 1.36 MB

english, 2014

39

Contribution of Proteoglycans to Human Immunodeficiency Virus Type 1 Brain Invasion

Bobardt, M. D., Salmon, P., Wang, L., Esko, J. D., Gabuzda, D., Fiala, M., Trono, D., Van der Schueren, B., David, G., Gallay, P. A.

Journal:

Journal of Virology

Year:

2004

Language:

english

File:

PDF, 491 KB

english, 2004

40

Long-Term Follow-Up in Patients with Indeterminate Barrett Esophagus

Becker, V., Bobardt, J., Ott, R., Rösch, T., Meining, A.

Journal:

Year:

2013

Language:

english

File:

PDF, 83 KB

english, 2013

41

The Cyclophilin Inhibitor SCY-635 Disrupts Hepatitis C Virus NS5A-Cyclophilin A Complexes

Hopkins, S., Bobardt, M., Chatterji, U., Garcia-Rivera, J. A., Lim, P., Gallay, P. A.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2012

Language:

english

File:

PDF, 1.51 MB

english, 2012

42

A Highly Conserved Arginine in gp120 Governs HIV-1 Binding to Both Syndecans and CCR5 via Sulfated Motifs

de Parseval, A., Bobardt, M. D., Chatterji, A., Chatterji, U., Elder, J. H., David, G., Zolla-Pazner, S., Farzan, M., Lee, T.-H., Gallay, P. A.

Journal:

Journal of Biological Chemistry

Year:

2005

Language:

english

File:

PDF, 1.39 MB

english, 2005

43

P0890 : Novel cyclophilin inhibitor CPI-431-32 shows broad spectrum antiviral activity by blocking replication of HCV, HBV and HIV-1 viruses

Gallay, P., Chatterji, U., Bobardt, M., Ure, D., Trepanier, D., Foster, R., Ordonez, C.

Journal:

Journal of Hepatology

Year:

2015

Language:

english

File:

PDF, 170 KB

english, 2015

44

The Isomerase Active Site of Cyclophilin A Is Critical for Hepatitis C Virus Replication

Chatterji, U., Bobardt, M., Selvarajah, S., Yang, F., Tang, H., Sakamoto, N., Vuagniaux, G., Parkinson, T., Gallay, P.

Journal:

Journal of Biological Chemistry

Year:

2009

Language:

english

File:

PDF, 1.09 MB

english, 2009

45

C5A Protects Macaques from Vaginal Simian-Human Immunodeficiency Virus Challenge

Veazey, Ronald S., Chatterji, Udayan, Bobardt, Michael, Russell-Lodrigue, Kasi E., Li, Jian, Wang, Xiaolei, Gallay, Philippe A.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2016

Language:

english

File:

PDF, 1.20 MB

english, 2016

46

O024 : Cyclophilin and NS5A inhibitors, but not other anti-HCV agents, preclude HCV-mediated formation of double membrane vesicle viral factories

Chatterji, U., Bobardt, M., Tai, A., De Francesco, R., Wood, M., Gallay, P.

Journal:

Journal of Hepatology

Year:

2015

Language:

english

File:

PDF, 43 KB

english, 2015

47

Characterization of the Anti-HCV Activities of the New Cyclophilin Inhibitor STG-175

Gallay, P., Chatterji, U., Bobardt, M., Long, Z., Zhang, S., Su, Z.

Journal:

Journal of Hepatology

Year:

2016

Language:

english

File:

PDF, 137 KB

english, 2016

48

Cyclophilin Inhibitors Remodel the Endoplasmic Reticulum of HCV-Infected Cells in a Unique Pattern Rendering Cells Impervious to a Second Infection

Chatterji, U., Bobardt, M., Wood, M., Gallay, P.

Journal:

Journal of Hepatology

Year:

2016

Language:

english

File:

PDF, 52 KB

english, 2016

49

DEB025 (Alisporivir) Inhibits Hepatitis C Virus Replication by Preventing a Cyclophilin A Induced Cis-Trans Isomerisation in Domain II of NS5A

Coelmont, Lotte, Hanoulle, Xavier, Chatterji, Udayan, Berger, Carola, Snoeck, Joke, Bobardt, Michael, Lim, Precious, Vliegen, Inge, Paeshuyse, Jan, Vuagniaux, Grégoire, Vandamme, Anne-Mieke, Bartensch

Journal:

Year:

2010

Language:

english

File:

PDF, 2.19 MB

english, 2010

50

HCV Core Residues Critical for Infectivity Are Also Involved in Core-NS5A Complex Formation

Gawlik, Katarzyna, Baugh, James, Chatterji, Udayan, Lim, Precious J., Bobardt, Michael D., Gallay, Philippe A., Polyak, Stephen J.

Journal:

Year:

2014

Language:

english

File:

PDF, 7.06 MB

english, 2014

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